- S 450 EQ Boost 4-matic (223.161) 280 kW
- S 450 e (223.166) 300 kW
- S 450 EQ Boost (223.160) 270 kW
- S 450 EQ Boost 4-matic (223.161) 270 kW
- S 500 EQ Boost 4-matic (223.163) 320 kW
- S 500 EQ Boost 4-matic (223.163) 330 kW
- S 580 e (223.168) 375 kW
- S 580 4-matic (223.176) 370 kW
- S 580 e 4-matic (223.169) 375 kW
- S 63 AMG Hybrid 4-matic (223.182) 590 kW
- S 350 d (223.130) 210 kW
- S 350 d 4-matic (223.131) 210 kW
- S 400 d 4-matic (223.133) 243 kW
- S 350 d Mild Hybrid (223.120) 230 kW
- S 350 d Mild Hybrid 4-matic (223.121) 230 kW
- S 450 d Mild Hybrid 4-matic (223.123) 270 kW